Description
Cactus reference-free alignments of GRCh38 and T2T CHM13 v2.0, using chimp
(GCF_002880755.1/panTro6) as an out-group.
Display Conventions and Configuration
This track uses the Snake tracks display conventions and configuration.
Methods
Alignments were generated using the Cactus reference alignment package and are stored
as a HAL file.
Data Access
The alignment summary can be explored interactively with the
Table Browser or the
Data Integrator.
The full multiple alignment is stored as a HAL file that can be downloaded from our
download server as
t2tChm13.v2.0.hal. HAL files can be queried and converted with the tools in the
HAL toolkit.
Please refer to our
mailing
list archives for questions, or our
Data Access FAQ for more
information.
Credits
This track was created by Marina Haukness <mhauknes@ucsc.edu>
if the UC Santa Cruz Computational Genomics Lab.
References
Armstrong J, Hickey G, Diekhans M, Fiddes IT, Novak AM, Deran A, Fang Q, Xie D, Feng S, Stiller J
et al.
Progressive Cactus is a multiple-genome aligner for the thousand-genome era.
Nature. 2020 Nov;587(7833):246-251.
PMID: 33177663; PMC: PMC7673649
Hickey G, Paten B, Earl D, Zerbino D, Haussler D.
HAL: a hierarchical format for storing and analyzing multiple genome alignments.
Bioinformatics. 2013 May 15;29(10):1341-2.
PMID: 23505295; PMC: PMC3654707